[Swarm-Modelling] population genetics

[Scott Christley]

Greetings,

Is anybody aware of research with an agent-based model (or other  
modeling approaches) that simulates evolution (recombination/ 
mutation) on actual genomic data?  I'm aware that genetic algorithms  
often use an artificial genome with attributes encoded in artificial  
genes, but I am looking for anybody who is using actual nucleotide  
sequence.  For example, a population genetics study may have  
sequenced a number of alleles for an organism, then use those alleles  
(and possible allele frequencies) to simulate and predict how  
environmental changes could affect the population diversity.  I am  
able to find empirical studies which record allozyme diversity across  
species, spatially, etc. but I have not found anybody doing  
simulations with the actual genomic data.

thanks
Scott